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Short- and middle-term continuous use of cinacalcet in children on peritoneal dialysis.

Dotis, John; Printza, Nikoleta; Ghogha, Chrisa; Papachristou, Fotios.
J Pediatr Endocrinol Metab; 26(1-2): 39-43, 2013.
Artigo em Inglês | MEDLINE | ID: mdl-23382299

BACKGROUND:

Secondary hyperparathyroidism (HPT) constitute a high-turnover bone disease, manifested by elevated parathyroid hormone. Cinacalcet, belonging to calcimimetics, has been shown to be promising in the control of secondary HPT with limited data in children.

OBJECTIVE:

To evaluate the safety and efficacy of cinacalcet in children on peritoneal dialysis (PD) with secondary HPT.

METHODS:

Four patients on PD with severe secondary HPT, uncontrolled with phosphorus dietary restrictions combined with phosphate binders and analog of 1,25 vitamin D3 received cinacalcet.

RESULTS:

After cinacalcet treatment, in two of four patients, we found a serum intact parathyroid hormone (iPTH) level reduction by more than 70% at 4 weeks and more than 60% at 3 or more than 6 months. Nevertheless, in the other two patients, a transient reduction of iPTH was found in 4 weeks and an increase in 3 or more months, who were finally treated with surgical parathyroidectomy. During cinacalcet treatment, no adverse events were noted.

CONCLUSION:

Cinacalcet may be a safe and effective treatment for PD patients with secondary HPT, although surgical parathyroidectomy cannot be avoided in certain cases.
Selo DaSilva