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Immunohistological features in adenomatoid odontogenic tumor: review of the literature and first expression and mutational analysis of ß-catenin in this unusual lesion of the jaws.

Harnet, Jean-Claude; Pedeutour, Florence; Raybaud, Hélène; Ambrosetti, Damien; Fabas, Thibault; Lombardi, Tommaso.
J Oral Maxillofac Surg; 71(4): 706-13, 2013 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-23265580

PURPOSE:

To investigate for the first time the immunohistochemical and mutational status of ß-catenin in a mandibular case of adenomatoid odontogenic tumor (AOT) and to review the immunohistochemical expression data of various markers (cytokeratins, metalloproteinases, etc) in such a lesion.

MATERIALS AND METHODS:

A case of follicular-type AOT in a young male patient was analyzed in regard to the immunohistochemical expression of ß-catenin and mutations of the ß-catenin gene (CTNNB1). Its expression is altered in some odontogenic tumors.

RESULTS:

We found a strong cytoplasmic expression of ß-catenin, but no molecular anomaly within the exon 3 of CTNNB1. ß-catenin is considered to play a role in cell differentiation processes.

CONCLUSION:

Our results were consistent with previous findings in ameloblastoma and malignant odontogenic tumors. However, ß-catenin alterations had not been explored in AOT so far. Further studies are necessary to understand the specific regulation of ß-catenin in the AOT pathogenesis.
Selo DaSilva