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High interleukin 17 expression is correlated with better cardiac function in human Chagas disease.

Magalhães, Luisa M D; Villani, Fernanda N A; Nunes, Maria do Carmo P; Gollob, Kenneth J; Rocha, Manoel O C; Dutra, Walderez O.
J Infect Dis; 207(4): 661-5, 2013 Feb 15.
Artigo em Inglês | MEDLINE | ID: mdl-23204182
This study was designed to investigate whether the expression of interleukin 17 (IL-17) is associated with the indeterminate or cardiac clinical forms of Chagas disease and whether IL-17 expression can be correlated with patients' cardiac function. Our results demonstrated that cardiac Chagas patients have a lower intensity of expression of IL-17 by total lymphocytes and lower frequency of circulating T helper 17 cells. Correlative analysis showed that high IL-17 expression was associated with better cardiac function, as determined by left ventricular ejection fraction and left ventricular diastolic diameter values. Therefore, IL-17 expression can be a protective factor to prevent myocardial damage in human Chagas disease.
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