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D-ring modified novel isosteviol derivatives: design, synthesis and cytotoxic activity evaluation.

Zhang, Tao; Lu, Li-Hui; Liu, Hao; Wang, Jun-Wei; Wang, Rui-Xue; Zhang, Yun-Xiao; Tao, Jing-Chao.
Bioorg Med Chem Lett; 22(18): 5827-32, 2012 Sep 15.
Artigo em Inglês | MEDLINE | ID: mdl-22901386
A series of polyhydric, amino alcohol and tricyclic derivatives were facilely synthesized by D-ring modification of isosteviol. These compounds were screened for their cytotoxic activities against four human tumor cell lines in vitro. Among them, the 15-α-aminomethyl-16-ß-hydroxyl isosteviol 23 exhibits significant cytotoxicity superior to the positive control (cisplatin) against EC9706, PC-3 and HCT-116 cell lines.
Selo DaSilva