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Solid organ transplant-associated lymphocytic choriomeningitis, United States, 2011.

Macneil, Adam; Ströher, Ute; Farnon, Eileen; Campbell, Shelley; Cannon, Deborah; Paddock, Christopher D; Drew, Clifton P; Kuehnert, Matthew; Knust, Barbara; Gruenenfelder, Robert; Zaki, Sherif R; Rollin, Pierre E; Nichol, Stuart T.
Emerg Infect Dis; 18(8): 1256-62, 2012 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-22839997
Three clusters of organ transplant-associated lymphocytic choriomeningitis virus (LCMV) transmissions have been identified in the United States; 9 of 10 recipients died. In February 2011, we identified a fourth cluster of organ transplant-associated LCMV infections. Diabetic ketoacidosis developed in the organ donor in December 2010; she died with generalized brain edema after a short hospitalization. Both kidneys, liver, and lung were transplanted to 4 recipients; in all 4, severe posttransplant illness developed; 2 recipients died. Through multiple diagnostic methods, we identified LCMV infection in all persons, including in at least 1 sample from the donor and 4 recipients by reverse transcription PCR, and sequences of a 396-bp fragment of the large segment of the virus from all 5 persons were identical. In this cluster, all recipients developed severe illness, but 2 survived. LCMV infection should be considered as a possible cause of severe posttransplant illness.
Selo DaSilva