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Listerial invasion protein internalin B promotes entry into ileal Peyer's patches in vivo.

Chiba, Sayuri; Nagai, Takeshi; Hayashi, Toshiyuki; Baba, Yukiko; Nagai, Shigenori; Koyasu, Shigeo.
Microbiol Immunol; 55(2): 123-9, 2011 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-21204945
Listeria monocytogenes (Lm) invades the host intestine using listerial invasion proteins, internalins. The in vivo role of internalin A (InlA) and internalin B (InlB) is reported here. Intragastric (i.g.) administration and ligated loop assays with ΔinlB-Lm demonstrated that a lack of InlB significantly attenuates the invasive ability of Lm into various organs. On the other hand, InlA(m)-Lm expressing a mutant InlA with two substitutions, S192N and Y369S, which has been reported to increase the affinity of InlA to mouse E-cadherin, resulted in little increase in intestinal infection according to both ligated loop and i.g. infection assays. Lm preferentially enters ileal Peyer's patch (PP) via M cells and ΔinlB-Lm showed severely reduced ability to invade though these cells. The present results reveal the importance of InlB, which accelerates listerial invasion into M cells on ileal PPs in vivo.
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