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Tripartite-motif proteins and innate immune regulation.

McNab, Finlay W; Rajsbaum, Ricardo; Stoye, Jonathan P; O'Garra, Anne.
Curr Opin Immunol; 23(1): 46-56, 2011 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-21131187
The tripartite motif containing (TRIM) proteins are a family of proteins that have been implicated in many biological processes including cell differentiation, apoptosis, transcriptional regulation and signaling pathways. Many TRIM proteins are upregulated by the immunologically important Type I and Type II interferons and several, including TRIM5α and TRIM19/PML, restrict viral replication. There is growing evidence that TRIMs also play an important role in the broader immune response through regulating signaling pathways such as the RIG-I pathway. In this review we discuss recent research elucidating TRIM regulation of a number of pathways important in immunity and review the latest findings relating to viral restriction by TRIMs.
Selo DaSilva