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The microRNA miR-182 is induced by IL-2 and promotes clonal expansion of activated helper T lymphocytes.

Stittrich, Anna-Barbara; Haftmann, Claudia; Sgouroudis, Evridiki; Kühl, Anja Andrea; Hegazy, Ahmed Nabil; Panse, Isabel; Riedel, Rene; Flossdorf, Michael; Dong, Jun; Fuhrmann, Franziska; Heinz, Gitta Anne; Fang, Zhuo; Li, Na; Bissels, Ute; Hatam, Farahnaz; Jahn, Angelina; Hammoud, Ben; Matz, Mareen; Schulze, Felix-Michael; Baumgrass, Ria; Bosio, Andreas; Mollenkopf, Hans-Joachim; Grün, Joachim; Thiel, Andreas; Chen, Wei; Höfer, Thomas; Loddenkemper, Christoph; Löhning, Max; Chang, Hyun-Dong; Rajewsky, Nikolaus; Radbruch, Andreas; Mashreghi, Mir-Farzin.
Nat Immunol; 11(11): 1057-62, 2010 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-20935646
After being activated by antigen, helper T lymphocytes switch from a resting state to clonal expansion. This switch requires inactivation of the transcription factor Foxo1, a suppressor of proliferation expressed in resting helper T lymphocytes. In the early antigen-dependent phase of expansion, Foxo1 is inactivated by antigen receptor-mediated post-translational modifications. Here we show that in the late phase of expansion, Foxo1 was no longer post-translationally regulated but was inhibited post-transcriptionally by the interleukin 2 (IL-2)-induced microRNA miR-182. Specific inhibition of miR-182 in helper T lymphocytes limited their population expansion in vitro and in vivo. Our results demonstrate a central role for miR-182 in the physiological regulation of IL-2-driven helper T cell-mediated immune responses and open new therapeutic possibilities.
Selo DaSilva