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Molecularly imprinted polymers as analyte sequesters and selective surfaces for easy ambient sonic-spray ionization.

Figueiredo, Eduardo Costa; Sanvido, Gustavo Braga; Arruda, Marco Aurélio Zezzi; Eberlin, Marcos Nogueira.
Analyst; 135(4): 726-30, 2010 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-20309446
The use of a molecularly imprinted polymer (MIP) as a selective surface for ambient mass spectrometry is demonstrated. The MIP is used to sequester target analytes from urine and easy ambient sonic-spray ionization mass spectrometry (EASI-MS) is shown to be able to efficiently desorb the analytes from the MIP surface and then transfer them in protonated forms to the gas phase for MS analysis. A set of five phenothiazines (chlorpromazine, perphenazine, triflupromazine, thioridazine and prochlorperazine) were chosen from a proof-of-principle class of drug samples. A chlorpromazine-imprinted methacrylic polymer was synthesized and used to prepare a MIP probe. The MIP-EASI-MS technique using acidified methanol as solvent has been shown to allow quantification of all five drugs in urine with LOQ of ca. 1 micromol L(-1).
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