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In vitro elution of daptomycin by a synthetic crystallic semihydrate form of calcium sulfate, stimulan.

Kanellakopoulou, Kyriaki; Panagopoulos, Periklis; Giannitsioti, Efthymia; Tsaganos, Thomas; Carrer, Dionyssia-Pinelopi; Efstathopoulos, Nicolas; Giamarellos-Bourboulis, Evangelos J.
Antimicrob Agents Chemother; 53(7): 3106-7, 2009 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-19398646
A synthetic crystallic semihydrate form of calcium sulfate, Stimulan, was evaluated as a biodegradable carrier for the daily in vitro elution of daptomycin. Daptomycin and Stimulan were admixed at a ratio of 95:5. Elution lasted for 28 days. Eluted concentrations peaked on days 1 and 11, when the mean values were 1,320.1 and 949.2 microg/ml, respectively. The lowest eluted concentration was detected on day 28. These results support the application of the system described in experimental models of osteomyelitis.
Selo DaSilva