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The cell adhesion molecule nectin-1 is critical for normal enamel formation in mice.

Barron, Martin J; Brookes, Steven J; Draper, Clare E; Garrod, David; Kirkham, Jennifer; Shore, Roger C; Dixon, Michael J.
Hum Mol Genet; 17(22): 3509-20, 2008 Nov 15.
Artigo em Inglês | MEDLINE | ID: mdl-18703497
Nectin-1 is a member of a sub-family of immunoglobulin-like adhesion molecules and a component of adherens junctions. In the current study, we have shown that mice lacking nectin-1 exhibit defective enamel formation in their incisor teeth. Although the incisors of nectin-1-null mice were hypomineralized, the protein composition of the enamel matrix was unaltered. While strong immunostaining for nectin-1 was observed at the interface between the maturation-stage ameloblasts and the underlying cells of the stratum intermedium (SI), its absence in nectin-1-null mice correlated with separation of the cell layers at this interface. Numerous, large desmosomes were present at this interface in wild-type mice; however, where adhesion persisted in the mutant mice, the desmosomes were smaller and less numerous. Nectins have been shown to regulate tight junction formation; however, this is the first report showing that they may also participate in the regulation of desmosome assembly. Importantly, our results show that integrity of the SI-ameloblast interface is essential for normal enamel mineralization.
Selo DaSilva