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Interféron-alpha: une cytokine clé dans la physiopathologie du lupus systémique. / [Interferon-alpha: a key cytokine in systemic lupus erythematosus pathogenesis].

Mathian, A; Koutouzov, S.
Rev Med Interne; 29(9): 696-700, 2008 Sep.
Artigo em Francês | MEDLINE | ID: mdl-18524426
Systemic lupus erythematosus (SLE) is a complex autoimmune disease characterized by a chronic inflammation affecting multiple tissues and the production of antibodies directed against nuclear antigens. Leading observations in patients suggested years ago that interferon-alpha (IFNalpha) was involved in SLE pathogenesis. These observations have now been confirmed in SLE-prone mice. New promising therapeutic strategies, aiming at neutralizing IFNalpha or its effects, are currently under development.
Selo DaSilva