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Targeting poly(ADP-ribose) polymerase: a two-armed strategy for cancer therapy.

Plummer, Elizabeth Ruth; Calvert, Hilary.
Clin Cancer Res; 13(21): 6252-6, 2007 Nov 01.
Artigo em Inglês | MEDLINE | ID: mdl-17975135
The DNA repair pathways are protective of the host genome in normal cells; however, in cancer cells, these pathways may be disrupted and predispose to tumorigenesis or their activity may overcome the potentially cytotoxic damage caused by anticancer agents and be a mechanism of resistance. Poly(ADP-ribose) polymerase inhibitors, which block base excision repair of single-strand breaks, have entered the clinic in the last few years. This article discusses the interactions between the pathways of single- and double-strand break repair, which explain the two clinical development strategies for this class of drugs.
Selo DaSilva