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Symptom resolution does not predict healing of erosive oesophagitis in Chinese.

Cheung, Ting Kin; Wong, Wai Man; Wong, Nina Y H; Chan, Chi Kuen; Fung, James; Yuen, Man Fung; Chan, Annie O O; Tong, Teresa S M; Wong, Benjamin C Y.
Digestion; 75(2-3): 128-34, 2007.
Artigo em Inglês | MEDLINE | ID: mdl-17671381

BACKGROUND:

Previous studies suggested that Chinese have a milder spectrum of gastro-oesophageal reflux disease and a lower dose of proton pump inhibitors (PPI) is sufficient for the control of symptoms as compared with the Western population.

AIMS:

To determine if 8 weeks of esomeprazole 20 mg daily would be adequate for both symptom resolution and oesophagitis healing in Chinese patients and the predictive factors for the response.

METHODS:

66 patients with oesophagitis were included. Oesophagitis severity was graded by Los Angeles (LA) classification. 61 patients underwent 24-hour ambulatory pH study at baseline. All were given esomeprazole 20 mg daily for 8 weeks. Symptom response and healing of oesophagitis was assessed at the end of the treatment period.

RESULTS:

75.8% of the patients had complete reflux symptom resolution but only 48% had complete healing of the oesophagitis at endoscopy after 8 weeks of treatment. LA classification grading at baseline endoscopy (p < 0.0001) and total number acid reflux episodes on 24-hour pH monitoring prior to treatment (p = 0.007) were both good predictors of oesophagitis healing but not for symptom resolution.

CONCLUSIONS:

Our results suggested that 8 weeks of lower dose PPI is not sufficient for oesophagitis healing. Symptom resolution with PPI does not predict oesophagitis healing in Chinese.
Selo DaSilva