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Mast cells enhance T cell activation: Importance of mast cell-derived TNF.

Nakae, Susumu; Suto, Hajime; Kakurai, Maki; Sedgwick, Jonathon D; Tsai, Mindy; Galli, Stephen J.
Proc Natl Acad Sci U S A; 102(18): 6467-72, 2005 May 03.
Artigo em Inglês | MEDLINE | ID: mdl-15840716
Mast cells are not only important effector cells in immediate hypersensitivity reactions and immune responses to pathogens but also can contribute to T cell-mediated disorders. However, the mechanisms by which mast cells might influence T cells in such settings are not fully understood. We find that mast cells can enhance proliferation and cytokine production in multiple T cell subsets. Mast cell-dependent enhancement of T cell activation can be promoted by FcepsilonRI-dependent mast cell activation, TNF production by both mast cells and T cells, and mast cell-T cell contact. However, at high concentrations of cells, mast cells can promote T cell activation independent of IgE or TNF. Finally, mast cells also can promote T cell activation by means of soluble factors. These findings identify multiple mechanisms by which mast cells can influence T cell proliferation and cytokine production.
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