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Hypomanic symptoms assessed by the HCL-32 in patients with major depressive disorder: a multicenter trial across China.

Yang, Hai-Chen; Xiang, Yu-Tao; Liu, Tie-Bang; Han, Rong; Wang, Gang; Hu, Chen; Li, Ling-Jiang; Wang, Xiao-Ping; Peng, Hong-Jun; Si, Tian-Mei; Fang, Yi-Ru; Yuan, Cheng-Mei; Lu, Zheng; Hu, Jian; Chen, Zhi-Yu; Huang, Yi; Sun, Jing; Li, Hui-Chun; Zhang, Jin-Bei; Angst, Jules.
J Affect Disord; 143(1-3): 203-7, 2012 Dec 20.
Artículo en Inglés | MEDLINE | ID: mdl-22840613

AIM:

To investigate the results of the Hypomania Checklist-32 (HCL-32) administered as a screening instrument in clinical settings to mood disorders patients in the depressive phase.

METHODS:

A total of 1487 patients diagnosed and being treated for major depressive disorder (MDD) in 13 mental health centers across China were self-rated by the HCL-32 and independently examined by the Mini International Neuropsychiatric Interview (MINI).

RESULTS:

After examination by the MINI, 309 (20.8%) of the 1487 patients clinically diagnosed as having MDD satisfied DSM-IV criteria for bipolar disorder (BD): 118 (7.9%) for bipolar I disorder (BD-I) and 191 (12.8%) for bipolar II disorder (BD-II). The mean HCL-32 score of the BD patients was statistically higher than that of patients with unipolar depression (UD, major depressive disorder), BD-II higher than UD, while no significant difference between BD-I and BD-II. The HCL-32 distinguished between BD and UD (best cutoff score 14), between BD-II and UD (best cutoff 12). At the optimum cutoff of 12 between BD and UD, the sensitivity was 0.86, specificity 0.69.

LIMITATIONS:

No standardized instruments were used to measure the severity of depressive symptoms. Depressed patients with a previous history of BD were excluded from this study.

CONCLUSIONS:

The HCL-32 results in this multicenter study of patients in the depressive phase were similar to those of earlier, generally smaller-scale studies which subjects could be in any mood phases. A score of 12 could be used as the optimum cutoff between BD and UD to improve screening for BD-II if the HCL-32 was applied in clinical settings in China.
Selo DaSilva