Genetic correlations of polygenic disease traits: from theory to practice.
van Rheenen, Wouter; Peyrot, Wouter J; Schork, Andrew J; Lee, S Hong; Wray, Naomi R.
Nat Rev Genet
; 20(10): 567-581, 2019 10.
Artigo em Inglês | MEDLINE | ID: mdl-31171865
Common Disease Is More Complex Than Implied by the Core Gene Omnigenic Model.
An Expanded View of Complex Traits: From Polygenic to Omnigenic.
Polygenic Risk Scores Expand to Obesity.
Extreme Polygenicity of Complex Traits Is Explained by Negative Selection.
Keeping score with obesity.
The role of sex in the genomics of human complex traits.
Making the case for more inclusive GWAS.
Distilling pathophysiology from complex disease genetics.
Concepts and Misconceptions about the Polygenic Additive Model Applied to Disease.
CoMM: a collaborative mixed model to dissecting genetic contributions to complex traits by leveraging regulatory information.