Acid ceramidase promotes drug resistance in acute myeloid leukemia through NF-κB-dependent P-glycoprotein upregulation.
Tan, Su-Fern; Dunton, Wendy; Liu, Xin; Fox, Todd E; Morad, Samy A F; Desai, Dhimant; Doi, Kenichiro; Conaway, Mark R; Amin, Shantu; Claxton, David F; Wang, Hong-Gang; Kester, Mark; Cabot, Myles C; Feith, David J; Loughran, Thomas P.
J Lipid Res
; 60(6): 1078-1086, 2019 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-30962310
Pregnane X Receptor Not Nuclear Factor-kappa B Up-regulates P-glycoprotein Expression in the Brain of Chronic Epileptic Rats Induced by Kainic Acid.
Drug resistance is conferred on the model yeast Saccharomyces cerevisiae by expression of full-length melanoma-associated human ATP-binding cassette transporter ABCB5.
Crystal structure of the multidrug transporter P-glycoprotein from Caenorhabditis elegans.
Gambogenic acid reverses P-glycoprotein mediated multidrug resistance in HepG2/Adr cells and its underlying mechanism.
Sequential phase II Southwest Oncology Group studies (S0112 and S0301) of daunorubicin and cytarabine by continuous infusion, without and with ciclosporin, in older patients with previously untreated acute myeloid leukaemia.
Inflammatory regulation of ATP binding cassette efflux transporter expression and function in microglia.
Combination of tetrandrine as a potential-reversing agent with daunorubicin, etoposide and cytarabine for the treatment of refractory and relapsed acute myelogenous leukemia.
The intestinal nematode inhibits T-cell reactivity by targeting P-GP activity.
P-glycoprotein inhibition using valspodar (PSC-833) does not improve outcomes for patients younger than age 60 years with newly diagnosed acute myeloid leukemia: Cancer and Leukemia Group B study 19808.
In silico screening for inhibitors of p-glycoprotein that target the nucleotide binding domains.