Humanized Mouse Model Mimicking Pathology of Human Tuberculosis for <i>in vivo</i> Evaluation of Drug Regimens.
Arrey, Frida; Löwe, Delia; Kuhlmann, Stefanie; Kaiser, Peggy; Moura-Alves, Pedro; Krishnamoorthy, Gopinath; Lozza, Laura; Maertzdorf, Jeroen; Skrahina, Tatsiana; Skrahina, Alena; Gengenbacher, Martin; Nouailles, Geraldine; Kaufmann, Stefan H E.
; 10: 89, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-30766535
The C3HeB/FeJ mouse model recapitulates the hallmark of bovine tuberculosis lung lesions following Mycobacterium bovis aerogenous infection.
Host evasion and exploitation schemes of Mycobacterium tuberculosis.
Heterogeneity in tuberculosis pathology, microenvironments and therapeutic responses.
From granuloma to fibrosis: sarcoidosis associated pulmonary fibrosis.
The role of the granuloma in expansion and dissemination of early tuberculous infection.
Computational modeling predicts IL-10 control of lesion sterilization by balancing early host immunity-mediated antimicrobial responses with caseation during mycobacterium tuberculosis infection.
CD4+ cell-dependent granuloma formation in humanized mice infected with mycobacteria.
Immunology studies in non-human primate models of tuberculosis.
Mouse model of necrotic tuberculosis granulomas develops hypoxic lesions.
Lymphangiogenesis is induced by mycobacterial granulomas via vascular endothelial growth factor receptor-3 and supports systemic T-cell responses against mycobacterial antigen.