Cardioprotective effects of the novel curcumin analogue C66 in diabetic mice is dependent on JNK2 inactivation.
Li, Cheng; Miao, Xiao; Lou, Yan; Lu, Zhengyang; Adhikari, Binay Kumar; Wang, Yangwei; Liu, Quan; Sun, Jian; Wang, Yonggang.
J Cell Mol Med
; 22(12): 6314-6326, 2018 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-30320490
Novel Curcumin C66 That Protects Diabetes-Induced Aortic Damage Was Associated with Suppressing JNK2 and Upregulating Nrf2 Expression and Function.
Inhibition of JNK by novel curcumin analog C66 prevents diabetic cardiomyopathy with a preservation of cardiac metallothionein expression.