Mechanism of dysfunction of human variants of the IRAK4 kinase and a role for its kinase activity in interleukin-1 receptor signaling.
De, Saurav; Karim, Fawziya; Kiessu, Ezechielle; Cushing, Leah; Lin, Lih-Ling; Ghandil, Pegah; Hoarau, Cyrille; Casanova, Jean-Laurent; Puel, Anne; Rao, Vikram R.
J Biol Chem
; 293(39): 15208-15220, 2018 09 28.
Artigo em Inglês | MEDLINE | ID: mdl-30115681
IRAK4 dimerization and trans-autophosphorylation are induced by Myddosome assembly.
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Crystal structure of human IRAK1.
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A narrow repertoire of transcriptional modules responsive to pyogenic bacteria is impaired in patients carrying loss-of-function mutations in MYD88 or IRAK4.
Sequential control of Toll-like receptor-dependent responses by IRAK1 and IRAK2.
Therapeutic Targeting of MLL Degradation Pathways in MLL-Rearranged Leukemia.
Interleukin-1 receptor-associated kinase 4 (IRAK4) plays a dual role in myddosome formation and Toll-like receptor signaling.
Small Molecule Inhibition of Interleukin-1 Receptor-Associated Kinase 4 (IRAK4).