Control of HIV-1 Pathogenesis in Viremic Nonprogressors Is Independent of Gag-Specific Cytotoxic T Lymphocyte Responses.
Salgado, Maria; Garcia-Minambres, Albert; Dalmau, Judith; Jiménez-Moyano, Esther; Viciana, Pompeyo; Alejos, Belén; Clotet, Bonaventura; Prado, Julia G; Martinez-Picado, Javier.
; 92(12)2018 06 15.
Artigo em Inglês | MEDLINE | ID: mdl-29593044
HIV Controllers Exhibit Enhanced Frequencies of Major Histocompatibility Complex Class II Tetramer<sup>+</sup> Gag-Specific CD4<sup>+</sup> T Cells in Chronic Clade C HIV-1 Infection.
Membrane metalloprotease TRABD2A restricts HIV-1 progeny production in resting CD4<sup>+</sup> T cells by degrading viral Gag polyprotein.
TCR clonotypes modulate the protective effect of HLA class I molecules in HIV-1 infection.
HIV-1 Antibody Neutralization Breadth Is Associated with Enhanced HIV-Specific CD4+ T Cell Responses.
Differential Gag-specific polyfunctional T cell maturation patterns in HIV-1 elite controllers.
HLA-B*14:02-Restricted Env-Specific CD8<sup>+</sup> T-Cell Activity Has Highly Potent Antiviral Efficacy Associated with Immune Control of HIV Infection.
Multiple Origins of Virus Persistence during Natural Control of HIV Infection.
Role of transmitted Gag CTL polymorphisms in defining replicative capacity and early HIV-1 pathogenesis.
CD8<sup>+</sup> T cells specific for conserved, cross-reactive Gag epitopes with strong ability to suppress HIV-1 replication.
Vaccine-induced immune responses against both Gag and Env improve control of simian immunodeficiency virus replication in rectally challenged rhesus macaques.