Synthesis and biological evaluation of pyridazinone derivatives as potential anti-inflammatory agents.
Barberot, Chantal; Moniot, Aurélie; Allart-Simon, Ingrid; Malleret, Laurette; Yegorova, Tatiana; Laronze-Cochard, Marie; Bentaher, Abderrazzaq; Médebielle, Maurice; Bouillon, Jean-Philippe; Hénon, Eric; Sapi, Janos; Velard, Frédéric; Gérard, Stéphane.
Eur J Med Chem
; 146: 139-146, 2018 Feb 25.
Artigo em Inglês | MEDLINE | ID: mdl-29407945
Design and Synthesis of Substituted Pyridazinone-1-Acetylhydrazones as Novel Phosphodiesterase 4 Inhibitors.
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Crisaborole Topical Ointment, 2%: A Nonsteroidal, Topical, Anti-Inflammatory Phosphodiesterase 4 Inhibitor in Clinical Development for the Treatment of Atopic Dermatitis.