Docosahexaenoic acid lowers cardiac mitochondrial enzyme activity by replacing linoleic acid in the phospholipidome.
Sullivan, E Madison; Pennington, Edward Ross; Sparagna, Genevieve C; Torres, Maria J; Neufer, P Darrell; Harris, Mitchel; Washington, James; Anderson, Ethan J; Zeczycki, Tonya N; Brown, David A; Shaikh, Saame Raza.
J Biol Chem
; 293(2): 466-483, 2018 01 12.
Artigo em Inglês | MEDLINE | ID: mdl-29162722
The phospholipase iPLA<sub>2</sub>Î³ is a major mediator releasing oxidized aliphatic chains from cardiolipin, integrating mitochondrial bioenergetics and signaling.
Increasing mitochondrial membrane phospholipid content lowers the enzymatic activity of electron transport complexes.
Cardiac mitochondrial energy metabolism in heart failure: Role of cardiolipin and sirtuins.
Fundamental Mechanisms of Regulated Cell Death and Implications for Heart Disease.
Kissing and nanotunneling mediate intermitochondrial communication in the heart.
Murine diet-induced obesity remodels cardiac and liver mitochondrial phospholipid acyl chains with differential effects on respiratory enzyme activity.
Mitochondrial CDP-diacylglycerol synthase activity is due to the peripheral protein, TAMM41 and not due to the integral membrane protein, CDP-diacylglycerol synthase 1.
The interactome of intact mitochondria by cross-linking mass spectrometry provides evidence for coexisting respiratory supercomplexes.
Thyroid state affects H<sub>2</sub>O<sub>2</sub> removal by rat heart mitochondria.
Lasalocid immediately and completely prevents the myocardial damage caused by coronary ischemia reperfusion in rat heart.