Complement C3 is a novel modulator of the anti-factor VIII immune response.
Rayes, Julie; Ing, Mathieu; Delignat, Sandrine; Peyron, Ivan; Gilardin, Laurent; Vogel, Carl-Wilhelm; Fritzinger, David C; Frémeaux-Bacchi, Véronique; Kaveri, Srinivas V; Roumenina, Lubka T; Lacroix-Desmazes, Sébastien.
; 103(2): 351-360, 2018 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-29146705
Modification of an exposed loop in the C1 domain reduces immune responses to factor VIII in hemophilia A mice.
Predictive immunogenicity of Refacto AF.
T cell response to FVIII.
Anti-factor VIII antibodies in brothers with haemophilia A share similar characteristics.
The C1 and C2 domains of blood coagulation factor VIII mediate its endocytosis by dendritic cells.
Marginal zone B cells are critical to factor VIII inhibitor formation in mice with hemophilia A.