A mutation in the viral sensor 2'-5'-oligoadenylate synthetase 2 causes failure of lactation.
Oakes, Samantha R; Gallego-Ortega, David; Stanford, Prudence M; Junankar, Simon; Au, Wendy Wing Yee; Kikhtyak, Zoya; von Korff, Anita; Sergio, Claudio M; Law, Andrew M K; Castillo, Lesley E; Allerdice, Stephanie L; Young, Adelaide I J; Piggin, Catherine; Whittle, Belinda; Bertram, Edward; Naylor, Matthew J; Roden, Daniel L; Donovan, Jesse; Korennykh, Alexei; Goodnow, Christopher C; O'Bryan, Moira K; Ormandy, Christopher J.
; 13(11): e1007072, 2017 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-29117179
ELTA: Enzymatic Labeling of Terminal ADP-Ribose.
Oligoadenylate-Synthetase-Family Protein OASL Inhibits Activity of the DNA Sensor cGAS during DNA Virus Infection to Limit Interferon Production.
Nuclear import sequence identification in hOAS3 protein.
Porcine 2', 5'-oligoadenylate synthetases inhibit Japanese encephalitis virus replication in vitro.
A novel RNA molecular signature for activation of 2'-5' oligoadenylate synthetase-1.
Origin and development of oligoadenylate synthetase immune system.
Long-term balancing selection at the antiviral gene OAS1 in Central African chimpanzees.
Activation of RNase L is dependent on OAS3 expression during infection with diverse human viruses.
OASL1 inhibits translation of the type I interferon-regulating transcription factor IRF7.
Antiviral activity of human OASL protein is mediated by enhancing signaling of the RIG-I RNA sensor.