Metabolic shift induced by systemic activation of T cells in PD-1-deficient mice perturbs brain monoamines and emotional behavior.
Miyajima, Michio; Zhang, Baihao; Sugiura, Yuki; Sonomura, Kazuhiro; Guerrini, Matteo M; Tsutsui, Yumi; Maruya, Mikako; Vogelzang, Alexis; Chamoto, Kenji; Honda, Kurara; Hikida, Takatoshi; Ito, Satomi; Qin, Hongyan; Sanuki, Rikako; Suzuki, Keiichiro; Furukawa, Takahisa; Ishihama, Yasushi; Matsuda, Fumihiko; Suematsu, Makoto; Honjo, Tasuku; Fagarasan, Sidonia.
; 18(12): 1342-1352, 2017 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-29058703
Anti-CD3 treatment up-regulates programmed cell death protein-1 expression on activated effector T cells and severely impairs their inflammatory capacity.
PD-1 Imposes Qualitative Control of Cellular Transcriptomes in Response to T Cell Activation.
Liver-Resident NK Cells Control Antiviral Activity of Hepatic T Cells via the PD-1-PD-L1 Axis.
A rheostat for immune responses: the unique properties of PD-1 and their advantages for clinical application.
LSD1 Ablation Stimulates Anti-tumor Immunity and Enables Checkpoint Blockade.
Structural insight into T cell coinhibition by PD-1H (VISTA).
Suppression of Exosomal PD-L1 Induces Systemic Anti-tumor Immunity and Memory.
FBXO38 mediates PD-1 ubiquitination and regulates anti-tumour immunity of T cells.
Dysfunctional CD8 T Cells Form a Proliferative, Dynamically Regulated Compartment within Human Melanoma.
Single-cell RNA-seq identifies a PD-1<sup>hi</sup> ILC progenitor and defines its development pathway.