Dynamic landscape and regulation of RNA editing in mammals.
Tan, Meng How; Li, Qin; Shanmugam, Raghuvaran; Piskol, Robert; Kohler, Jennefer; Young, Amy N; Liu, Kaiwen Ivy; Zhang, Rui; Ramaswami, Gokul; Ariyoshi, Kentaro; Gupte, Ankita; Keegan, Liam P; George, Cyril X; Ramu, Avinash; Huang, Ni; Pollina, Elizabeth A; Leeman, Dena S; Rustighi, Alessandra; Goh, Y P Sharon; Chawla, Ajay; Del Sal, Giannino; Peltz, Gary; Brunet, Anne; Conrad, Donald F; Samuel, Charles E; O'Connell, Mary A; Walkley, Carl R; Nishikura, Kazuko; Li, Jin Billy.
; 550(7675): 249-254, 2017 10 11.
Artigo em Inglês | MEDLINE | ID: mdl-29022589
The origin of the ADAR gene family and animal RNA editing.
ADAR1: A New Target for Immuno-oncology Therapy.
TRIBE: Hijacking an RNA-Editing Enzyme to Identify Cell-Specific Targets of RNA-Binding Proteins.
RNA decay: The anti-apoptotic function of ADAR1.
The Other Face of an Editor: ADAR1 Functions in Editing-Independent Ways.
ADAR1 forms a complex with Dicer to promote microRNA processing and RNA-induced gene silencing.
The solution structure of the ADAR2 dsRBM-RNA complex reveals a sequence-specific readout of the minor groove.
DHX9 suppresses RNA processing defects originating from the Alu invasion of the human genome.
Adenosine deaminase acting on RNA (ADAR1), a suppressor of double-stranded RNA-triggered innate immune responses.
ADAR2 affects mRNA coding sequence edits with only modest effects on gene expression or splicing in vivo.