Transition State Analogue Inhibitors of 5'-Deoxyadenosine/5'-Methylthioadenosine Nucleosidase from Mycobacterium tuberculosis.
Namanja-Magliano, Hilda A; Evans, Gary B; Harijan, Rajesh K; Tyler, Peter C; Schramm, Vern L.
; 56(38): 5090-5098, 2017 09 26.
Artigo em Inglês | MEDLINE | ID: mdl-28836767
Neutron structures of the Helicobacter pylori 5'-methylthioadenosine nucleosidase highlight proton sharing and protonation states.
6-Methylpurine derived sugar modified nucleosides: Synthesis and evaluation of their substrate activity with purine nucleoside phosphorylases.
Modulating Enzyme Catalysis through Mutations Designed to Alter Rapid Protein Dynamics.
Catalytic site cooperativity in dimeric methylthioadenosine nucleosidase.
Entropy-driven binding of picomolar transition state analogue inhibitors to human 5'-methylthioadenosine phosphorylase.
Four generations of transition-state analogues for human purine nucleoside phosphorylase.
A picomolar transition state analogue inhibitor of MTAN as a specific antibiotic for Helicobacter pylori.
Tight binding enantiomers of pre-clinical drug candidates.
Inverse enzyme isotope effects in human purine nucleoside phosphorylase with heavy asparagine labels.
Discovery of new inhibitors of Schistosoma mansoni PNP by pharmacophore-based virtual screening.