Cortical actin recovery at the immunological synapse leads to termination of lytic granule secretion in cytotoxic T lymphocytes.
Ritter, Alex T; Kapnick, Senta M; Murugesan, Sricharan; Schwartzberg, Pamela L; Griffiths, Gillian M; Lippincott-Schwartz, Jennifer.
Proc Natl Acad Sci U S A
; 114(32): E6585-E6594, 2017 08 08.
Artigo em Inglês | MEDLINE | ID: mdl-28716933
A newly identified isoform of Slp2a associates with Rab27a in cytotoxic T cells and participates to cytotoxic granule secretion.
Polygenic mutations in the cytotoxicity pathway increase susceptibility to develop HLH immunopathology in mice.
Specific Decrease in B-Cell-Derived Extracellular Vesicles Enhances Post-Chemotherapeutic CD8<sup>+</sup> T Cell Responses.
Molecular mechanisms regulating secretory organelles and endosomes in neutrophils and their implications for inflammation.
Synaptic release of CCL5 storage vesicles triggers CXCR4 surface expression promoting CTL migration in response to CXCL12.
LYST controls the biogenesis of the endosomal compartment required for secretory lysosome function.
Genetic deletion of Rab27B in pancreatic acinar cells affects granules size and has inhibitory effects on amylase secretion.
HIV-1 Nef Impairs the Formation of Calcium Membrane Territories Controlling the Signaling Nanoarchitecture at the Immunological Synapse.
Rab27a and Rab27b regulate neutrophil azurophilic granule exocytosis and NADPH oxidase activity by independent mechanisms.
Exophilin4/Slp2-a targets glucagon granules to the plasma membrane through unique Ca2+-inhibitory phospholipid-binding activity of the C2A domain.