Development of CNS multi-receptor ligands: Modification of known D2 pharmacophores.
Etukala, Jagan R; Zhu, Xue Y; Eyunni, Suresh V K; Onyameh, Edem K; Ofori, Edward; Bricker, Barbara A; Kang, Hye J; Huang, Xi-Ping; Roth, Bryan L; Ablordeppey, Seth Y.
Bioorg Med Chem
; 24(16): 3671-9, 2016 08 15.
Artigo em Inglês | MEDLINE | ID: mdl-27364609
Synthesis, Biological, and Computational Evaluation of Substituted 1-(2-Methoxyphenyl)-4-(1-phenethylpiperidin-4-yl)piperazines and 1-(2-Methoxyphenyl)-4-[(1-phenethylpiperidin-4-yl)methyl]piperazines as Dopaminergic Ligands.
Role of Loop-Clamping Side Chains in Catalysis by Triosephosphate Isomerase.
Electronic control of ligand-binding preference of a myoglobin mutant.
Regional and source-based patterns of [<sup>11</sup>C]-(+)-PHNO binding potential reveal concurrent alterations in dopamine D<sub>2</sub> and D<sub>3</sub> receptor availability in cocaine-use disorder.
Brexpiprazole I: in vitro and in vivo characterization of a novel serotonin-dopamine activity modulator.
Characterization of Brain Metabolism by Nuclear Magnetic Resonance.
Design and synthesis of dual 5-HT1A and 5-HT7 receptor ligands.
Identification and Synthesis of (Z,Z)-8,11-Heptadecadienyl Formate and (Z)-8-Heptadecenyl Formate: Unsaturated Aliphatic Formates Found in the Unidentified Astigmatid Mite, Sancassania sp. Sasagawa (Acari: Acaridae).
Pyrido[3,4-d]pyrimidin-4(3H)-one metabolism mediated by aldehyde oxidase is blocked by C2-substitution.
Biotransformations of Flavones and an Isoflavone (Daidzein) in Cultures of Entomopathogenic Filamentous Fungi.