Allele-specific DNA methylation reinforces PEAR1 enhancer activity.
Izzi, Benedetta; Pistoni, Mariaelena; Cludts, Katrien; Akkor, Pinar; Lambrechts, Diether; Verfaillie, Catherine; Verhamme, Peter; Freson, Kathleen; Hoylaerts, Marc F.
; 128(7): 1003-12, 2016 08 18.
Artigo em Inglês | MEDLINE | ID: mdl-27313330
Clonal analysis of lineage fate in native haematopoiesis.
Overexpression of heparanase in mice promoted megakaryopoiesis.
Germline variants in ETV6 underlie reduced platelet formation, platelet dysfunction and increased levels of circulating CD34+ progenitors.
C3G, through its GEF activity, induces megakaryocytic differentiation and proplatelet formation.
A hyperactive Mpl-based cell growth switch drives macrophage-associated erythropoiesis through an erythroid-megakaryocytic precursor.
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RUNX1 represses the erythroid gene expression program during megakaryocytic differentiation.