The Noncanonical Role of ULK/ATG1 in ER-to-Golgi Trafficking Is Essential for Cellular Homeostasis.
Joo, Joung Hyuck; Wang, Bo; Frankel, Elisa; Ge, Liang; Xu, Lu; Iyengar, Rekha; Li-Harms, XiuJie; Wright, Christopher; Shaw, Timothy I; Lindsten, Tullia; Green, Douglas R; Peng, Junmin; Hendershot, Linda M; Kilic, Fusun; Sze, Ji Ying; Audhya, Anjon; Kundu, Mondira.
; 62(4): 491-506, 2016 05 19.
Artigo em Inglês | MEDLINE | ID: mdl-27203176
Mechanisms of Autophagy Initiation.
The ER-Localized Transmembrane Protein EPG-3/VMP1 Regulates SERCA Activity to Control ER-Isolation Membrane Contacts for Autophagosome Formation.
Spodoptera litura autophagy-related protein 1 interacts with autophagy-related protein 5 and enhances its degradation.
ULK1/2 Constitute a Bifurcate Node Controlling Glucose Metabolic Fluxes in Addition to Autophagy.
ULK1 phosphorylates Sec23A and mediates autophagy-induced inhibition of ER-to-Golgi traffic.
VPS34 Acetylation Controls Its Lipid Kinase Activity and the Initiation of Canonical and Non-canonical Autophagy.
Cyclic dinucleotides trigger ULK1 (ATG1) phosphorylation of STING to prevent sustained innate immune signaling.
Identification of PPM1D as an essential Ulk1 phosphatase for genotoxic stress-induced autophagy.
Autophagosome formation is initiated at phosphatidylinositol synthase-enriched ER subdomains.
The Incredible ULKs: Autophagy and Beyond.