Cas-Database: web-based genome-wide guide RNA library design for gene knockout screens using CRISPR-Cas9.
Park, Jeongbin; Kim, Jin-Soo; Bae, Sangsu.
; 32(13): 2017-23, 2016 07 01.
Artigo em Inglês | MEDLINE | ID: mdl-27153724
Engineering complex synthetic transcriptional programs with CRISPR RNA scaffolds.
Human genetic variation alters CRISPR-Cas9 on- and off-targeting specificity at therapeutically implicated loci.
Double nicking by RNA-guided CRISPR Cas9 for enhanced genome editing specificity.
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Structural basis of CRISPR-SpyCas9 inhibition by an anti-CRISPR protein.
Repurposing CRISPR as an RNA-guided platform for sequence-specific control of gene expression.
Whole genome analysis of CRISPR Cas9 sgRNA off-target homologies via an efficient computational algorithm.
Structural basis of PAM-dependent target DNA recognition by the Cas9 endonuclease.
Expanding the CRISPR Toolbox: Targeting RNA with Cas13b.
Crystal Structure of Staphylococcus aureus Cas9.