General Framework for Meta-Analysis of Haplotype Association Tests.
Wang, Shuai; Zhao, Jing Hua; An, Ping; Guo, Xiuqing; Jensen, Richard A; Marten, Jonathan; Huffman, Jennifer E; Meidtner, Karina; Boeing, Heiner; Campbell, Archie; Rice, Kenneth M; Scott, Robert A; Yao, Jie; Schulze, Matthias B; Wareham, Nicholas J; Borecki, Ingrid B; Province, Michael A; Rotter, Jerome I; Hayward, Caroline; Goodarzi, Mark O; Meigs, James B; Dupuis, Josée.
; 40(3): 244-52, 2016 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-27027517
Microbiota-generated metabolites promote metabolic benefits via gut-brain neural circuits.
Selective Inhibition of FOXO1 Activator/Repressor Balance Modulates Hepatic Glucose Handling.
Susceptibility to type 2 diabetes may be modulated by haplotypes in G6PC2, a target of positive selection.
Crystal structures reveal a new and novel FoxO1 binding site within the human glucose-6-phosphatase catalytic subunit 1 gene promoter.
Hepatocytes contribute to residual glucose production in a mouse model for glycogen storage disease type Ia.
The five glucose-6-phosphatase paralogous genes are differentially regulated by insulin alone or combined with high level of amino acids and/or glucose in trout hepatocytes.
Moving on from GWAS: functional studies on the G6PC2 gene implicated in the regulation of fasting blood glucose.
Common variants at the GCK, GCKR, G6PC2-ABCB11 and MTNR1B loci are associated with fasting glucose in two Asian populations.
Long-term safety and efficacy of AAV gene therapy in the canine model of glycogen storage disease type Ia.
Dietary exacerbation of metabolic stress leads to accelerated hepatic carcinogenesis in glycogen storage disease type Ia.