The CASTOR Proteins Are Arginine Sensors for the mTORC1 Pathway.
Chantranupong, Lynne; Scaria, Sonia M; Saxton, Robert A; Gygi, Melanie P; Shen, Kuang; Wyant, Gregory A; Wang, Tim; Harper, J Wade; Gygi, Steven P; Sabatini, David M.
; 165(1): 153-164, 2016 Mar 24.
Artigo em Inglês | MEDLINE | ID: mdl-26972053
mTORC1 Activator SLC38A9 Is Required to Efflux Essential Amino Acids from Lysosomes and Use Protein as a Nutrient.
The cytotoxic T cell proteome and its shaping by the kinase mTOR.
SLC38A9 is a component of the lysosomal amino acid sensing machinery that controls mTORC1.
Regulation of TORC1 in response to amino acid starvation via lysosomal recruitment of TSC2.
mTORC1: turning off is just as important as turning on.
The Target of Rapamycin and Mechanisms of Cell Growth.
Spatial control of the TSC complex integrates insulin and nutrient regulation of mTORC1 at the lysosome.
Cellular differences in protein synthesis regulate tissue homeostasis.
Intersubunit Crosstalk in the Rag GTPase Heterodimer Enables mTORC1 to Respond Rapidly to Amino Acid Availability.
Inhibition of mTORC1 by astrin and stress granules prevents apoptosis in cancer cells.