Endogenous Formaldehyde Is a Hematopoietic Stem Cell Genotoxin and Metabolic Carcinogen.
Pontel, Lucas B; Rosado, Ivan V; Burgos-Barragan, Guillermo; Garaycoechea, Juan I; Yu, Rui; Arends, Mark J; Chandrasekaran, Gayathri; Broecker, Verena; Wei, Wei; Liu, Limin; Swenberg, James A; Crossan, Gerry P; Patel, Ketan J.
; 60(1): 177-88, 2015 Oct 01.
Artigo em Inglês | MEDLINE | ID: mdl-26412304
Alcohol and endogenous aldehydes damage chromosomes and mutate stem cells.
Rad18 confers hematopoietic progenitor cell DNA damage tolerance independently of the Fanconi Anemia pathway in vivo.
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Genotoxic consequences of endogenous aldehydes on mouse haematopoietic stem cell function.
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