Simultaneous Determination of Metformin, Metoprolol and its Metabolites in Rat Plasma by LC-MS-MS: Application to Pharmacokinetic Interaction Study.
Ma, Yan-rong; Rao, Zhi; Shi, A-xi; Wang, Ya-feng; Huang, Jing; Han, Miao; Wang, Xin-dong; Jin, Yong-wen; Zhang, Guo-qiang; Zhou, Yan; Zhang, Fan; Qin, Hong-yan; Wu, Xin-an.
J Chromatogr Sci
; 54(1): 1-9, 2016 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-26187926
Development of a LC-MS/MS method for simultaneous determination of metoprolol and its metabolites, α-hydroxymetoprolol and O-desmethylmetoprolol, in rat plasma: application to the herb-drug interaction study of metoprolol and breviscapine.
How do different extracorporeal circulation systems affect metoprolol bioavailability in coronary artery bypass surgery patients.
Simultaneous determination of metoprolol and its metabolites, α-hydroxymetoprolol and O-desmethylmetoprolol, in human plasma by liquid chromatography with tandem mass spectrometry: Application to the pharmacokinetics of metoprolol associated with CYP2D6 genotypes.
Quantification of Bisoprolol and Metoprolol in Simultaneous Human Serum and Cerebrospinal Fluid Samples.
Conscious and anaesthetised Göttingen mini-pigs as an in-vivo model for buccal absorption - pH-dependent absorption of metoprolol from bioadhesive tablets.
Stereoselective analysis of metoprolol and its metabolites in rat plasma with application to oxidative metabolism.
Determination of metoprolol enantiomers in human plasma and saliva samples utilizing microextraction by packed sorbent and liquid chromatography-tandem mass spectrometry.
Validated LC-ESI-MS/MS method for simultaneous quantitation of felodipine and metoprolol in rat plasma: application to a pharmacokinetic study in rats.
Simultaneous determination of metoprolol succinate and amlodipine besylate in human plasma by liquid chromatography-tandem mass spectrometry method and its application in bioequivalence study.
Metoprolol decreases the plasma exposure of metformin via the induction of liver, kidney and muscle uptake in rats.