Functional Anatomy of the Human Microprocessor.
Nguyen, Tuan Anh; Jo, Myung Hyun; Choi, Yeon-Gil; Park, Joha; Kwon, S Chul; Hohng, Sungchul; Kim, V Narry; Woo, Jae-Sung.
; 161(6): 1374-87, 2015 Jun 04.
Artigo em Inglês | MEDLINE | ID: mdl-26027739
Molecular Basis for the Single-Nucleotide Precision of Primary microRNA Processing.
Structure of Human DROSHA.
Beyond secondary structure: primary-sequence determinants license pri-miRNA hairpins for processing.
Dicer loss and recovery induce an oncogenic switch driven by transcriptional activation of the oncofetal Imp1-3 family.
Stress induces p38 MAPK-mediated phosphorylation and inhibition of Drosha-dependent cell survival.
Dual regulation of miRNA biogenesis generates target specificity in neurotrophin-induced protein synthesis.
HP1BP3, a Chromatin Retention Factor for Co-transcriptional MicroRNA Processing.
A heterotrimer model of the complete Microprocessor complex revealed by single-molecule subunit counting.
Posttranscriptional crossregulation between Drosha and DGCR8.
Alternative splicing affects the subcellular localization of Drosha.