Invariant NKT cells require autophagy to coordinate proliferation and survival signals during differentiation.
Pei, Bo; Zhao, Meng; Miller, Brian C; Véla, Jose Luis; Bruinsma, Monique W; Virgin, Herbert W; Kronenberg, Mitchell.
; 194(12): 5872-84, 2015 Jun 15.
Artigo em Inglês | MEDLINE | ID: mdl-25926673
Biology of CD1- and MR1-restricted T cells.
Regulation of ligands for the NKG2D activating receptor.
Polymorphisms in the CD1d promoter that regulate CD1d gene expression are associated with impaired NKT cell development.
Sphingolipids from a symbiotic microbe regulate homeostasis of host intestinal natural killer T cells.
Inflammation-induced formation of fat-associated lymphoid clusters.
The Immunology of CD1- and MR1-Restricted T Cells.
Regulatory iNKT cells lack expression of the transcription factor PLZF and control the homeostasis of T(reg) cells and macrophages in adipose tissue.
Elevated and sustained expression of the transcription factors Egr1 and Egr2 controls NKT lineage differentiation in response to TCR signaling.
Peroxisome-derived lipids are self antigens that stimulate invariant natural killer T cells in the thymus.
A locus on mouse chromosome 13 inversely regulates CD1d expression and the development of invariant natural killer T-cells.