An inherited duplication at the gene p21 Protein-Activated Kinase 7 (PAK7) is a risk factor for psychosis.
Morris, Derek W; Pearson, Richard D; Cormican, Paul; Kenny, Elaine M; O'Dushlaine, Colm T; Perreault, Louis-Philippe Lemieux; Giannoulatou, Eleni; Tropea, Daniela; Maher, Brion S; Wormley, Brandon; Kelleher, Eric; Fahey, Ciara; Molinos, Ines; Bellini, Stefania; Pirinen, Matti; Strange, Amy; Freeman, Colin; Thiselton, Dawn L; Elves, Rachel L; Regan, Regina; Ennis, Sean; Dinan, Timothy G; McDonald, Colm; Murphy, Kieran C; O'Callaghan, Eadbhard; Waddington, John L; Walsh, Dermot; O'Donovan, Michael; Grozeva, Detelina; Craddock, Nick; Stone, Jennifer; Scolnick, Ed; Purcell, Shaun; Sklar, Pamela; Coe, Bradley; Eichler, Evan E; Ophoff, Roel; Buizer, Jacobine; Szatkiewicz, Jin; Hultman, Christina; Sullivan, Patrick; Gurling, Hugh; Mcquillin, Andrew; St Clair, David; Rees, Elliott; Kirov, George; Walters, James; Blackwood, Douglas; Johnstone, Mandy; Donohoe, Gary.
Hum Mol Genet
; 23(12): 3316-26, 2014 Jun 15.
Artigo em Inglês | MEDLINE | ID: mdl-24474471
Signaling, Regulation, and Specificity of the Type II p21-activated Kinases.
Identification of a major determinant for serine-threonine kinase phosphoacceptor specificity.
Comprehensive profiling of the STE20 kinase family defines features essential for selective substrate targeting and signaling output.
CDC42 binds PAK4 via an extended GTPase-effector interface.
PAK4 crystal structures suggest unusual kinase conformational movements.
P21 activated kinase signaling in cancer.
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P21-activated kinase 1 and 4 were associated with colorectal cancer metastasis and infiltration.