Drebrin E depletion in human intestinal epithelial cells mimics Rab8a loss of function.
Vacca, Barbara; Bazellières, Elsa; Nouar, Roqiya; Harada, Akihiro; Massey-Harroche, Dominique; Le Bivic, André.
Hum Mol Genet
; 23(11): 2834-46, 2014 Jun 01.
Artigo em Inglês | MEDLINE | ID: mdl-24399445
Disruption of Rab8a and Rab11a causes formation of basolateral microvilli in neonatal enteropathy.
The Rab8 GTPase regulates apical protein localization in intestinal cells.
Rab7b modulates autophagic flux by interacting with Atg4B.
Abnormal Rab11-Rab8-vesicles cluster in enterocytes of patients with microvillus inclusion disease.
Rab8a and Rab8b are essential for several apical transport pathways but insufficient for ciliogenesis.
Shot and Patronin polarise microtubules to direct membrane traffic and biogenesis of microvilli in epithelia.
An integrated approach to uncover drivers of cancer.
Drosophila S2 cells secrete wingless on exosome-like vesicles but the wingless gradient forms independently of exosomes.
Occupation of nucleotide in the binding pocket is critical to the stability of Rab11A.
Cellular functions of Rab GTPases at a glance.