The histone H3 lysine 9 methyltransferases G9a and GLP regulate polycomb repressive complex 2-mediated gene silencing.
Mozzetta, Chiara; Pontis, Julien; Fritsch, Lauriane; Robin, Philippe; Portoso, Manuela; Proux, Caroline; Margueron, Raphaël; Ait-Si-Ali, Slimane.
; 53(2): 277-89, 2014 Jan 23.
Artigo em Inglês | MEDLINE | ID: mdl-24389103
Gene expression: methyltransferases 'talk' at histone H3.
A subset of the histone H3 lysine 9 methyltransferases Suv39h1, G9a, GLP, and SETDB1 participate in a multimeric complex.
Single-cell dynamics of genome-nuclear lamina interactions.
R-loops induce repressive chromatin marks over mammalian gene terminators.
Methylation of DNA Ligase 1 by G9a/GLP Recruits UHRF1 to Replicating DNA and Regulates DNA Methylation.
A post-translational modification switch controls coactivator function of histone methyltransferases G9a and GLP.
Human LSD2/KDM1b/AOF1 regulates gene transcription by modulating intragenic H3K4me2 methylation.
G9a functions as a molecular scaffold for assembly of transcriptional coactivators on a subset of glucocorticoid receptor target genes.
DNA damage signaling triggers degradation of histone methyltransferases through APC/C(Cdh1) in senescent cells.
Downregulation of histone methyltransferase EHMT2 in CD4<sup>+</sup> T-cells may protect HTLV-1-infected individuals against HAM/TSP development.