The tumor necrosis factor-like cytokine 1A/death receptor 3 cytokine system in intestinal inflammation.
Bamias, Giorgos; Jia, Li-Guo; Cominelli, Fabio.
Curr Opin Gastroenterol
; 29(6): 597-602, 2013 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-24100723
The TNF-family ligand TL1A and its receptor DR3 promote T cell-mediated allergic immunopathology by enhancing differentiation and pathogenicity of IL-9-producing T cells.
The TNF-family receptor DR3 is essential for diverse T cell-mediated inflammatory diseases.
TL1A selectively enhances IL-12/IL-18-induced NK cell cytotoxicity against NK-resistant tumor targets.
TL1A and DR3, a TNF family ligand-receptor pair that promotes lymphocyte costimulation, mucosal hyperplasia, and autoimmune inflammation.
The adaptor protein TRADD is essential for TNF-like ligand 1A/death receptor 3 signaling.
On death receptor 3 and its ligands .
Sustained TL1A expression modulates effector and regulatory T-cell responses and drives intestinal goblet cell hyperplasia.
Human group3 innate lymphoid cells express DR3 and respond to TL1A with enhanced IL-22 production and IL-2-dependent proliferation.
T cell expression of IL-18R and DR3 is essential for non-cognate stimulation of Th1 cells and optimal clearance of intracellular bacteria.
Shared αß TCR Usage in Lungs of Sarcoidosis Patients with Löfgren's Syndrome.