B-cell progenitors and precursors change their microenvironment in fetal liver during early development.
Tsuneto, Motokazu; Tokoyoda, Koji; Kajikhina, Ekaterina; Hauser, Anja E; Hara, Takahiro; Tani-Ichi, Shizue; Ikuta, Koichi; Melchers, Fritz.
; 31(12): 2800-12, 2013 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-23666739
Single-cell trajectory detection uncovers progression and regulatory coordination in human B cell development.
Stage-specific control of early B cell development by the transcription factor Ikaros.
The transcription repressors Bach2 and Bach1 promote B cell development by repressing the myeloid program.
The earliest thymic T cell progenitors sustain B cell and myeloid lineage potential.
Flexible ordering of antibody class switch and V(D)J joining during B-cell ontogeny.
Global changes in the nuclear positioning of genes and intra- and interdomain genomic interactions that orchestrate B cell fate.
Distorted antibody repertoire developed in the absence of pre-B cell receptor formation.
Generation of precursor, immature, and mature murine B1-cell lines from c-myc/bcl-xL-overexpressing pre-BI cells.
Macrophage colony-stimulating factor receptor marks and regulates a fetal myeloid-primed B-cell progenitor in mice.
Microbial colonization influences early B-lineage development in the gut lamina propria.