Susceptibility-associated genetic variation at IL12B enhances Th1 polarization in psoriasis.
Johnston, Andrew; Xing, Xianying; Swindell, William R; Kochkodan, James; Riblett, Marybeth; Nair, Rajan P; Stuart, Philip E; Ding, Jun; Voorhees, John J; Elder, James T; Gudjonsson, Johann E.
Hum Mol Genet
; 22(9): 1807-15, 2013 May 01.
Artigo em Inglês | MEDLINE | ID: mdl-23376980
Effect of polymorphisms in IL-12B p40, IL-17A and IL-23 A/G genes on the response of psoriatic patients to narrowband UVB.
Genetic variations in the IL-12B gene in association with IL-23 and IL-12p40 serum levels in ankylosing spondylitis.
Mixed results with modulation of TH-17 cells in human autoimmune diseases.
Up-regulation of Th17 and related cytokines in Behçet's disease corresponding to disease activity.
Targeted Reconstitution of Cytokine Activity upon Antigen Binding using Split Cytokine Antibody Fusion Proteins.
Whole blood stimulation with Toll-like receptor (TLR)-7/8 and TLR-9 agonists induces interleukin-12p40 expression in plasmacytoid dendritic cells in rhesus macaques but not in humans.
Principal role of IL-12p40 in the decreased Th1 and Th17 responses driven by dendritic cells of mice lacking IL-12 and IL-18.
IL-10, IL-12B and IL-17 gene polymorphisms in patients with mixed connective tissue disease.
Impact of Notch1 Deletion in Macrophages on Proinflammatory Cytokine Production and the Outcome of Experimental Autoimmune Encephalomyelitis.
Anti-IL-12/23 p40 antibody attenuates experimental chronic graft-versus-host disease via suppression of IFN-Î³/IL-17-producing cells.