GATA3 suppresses metastasis and modulates the tumour microenvironment by regulating microRNA-29b expression.
Chou, Jonathan; Lin, Jeffrey H; Brenot, Audrey; Kim, Jung-whan; Provot, Sylvain; Werb, Zena.
Nat Cell Biol
; 15(2): 201-13, 2013 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-23354167
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An Id2<sup>RFP</sup>-Reporter Mouse Redefines Innate Lymphoid Cell Precursor Potentials.
The ubiquitin ligase SCF<sup>FBXW7α</sup> promotes GATA3 degradation.
Group 3 innate lymphoid cells continuously require the transcription factor GATA-3 after commitment.
A monoallelic-to-biallelic T-cell transcriptional switch regulates GATA3 abundance.
Enhancer activation requires trans-recruitment of a mega transcription factor complex.
GATA3 expression in triple-negative breast cancers.