Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis.
Anastasiou, Dimitrios; Yu, Yimin; Israelsen, William J; Jiang, Jian-Kang; Boxer, Matthew B; Hong, Bum Soo; Tempel, Wolfram; Dimov, Svetoslav; Shen, Min; Jha, Abhishek; Yang, Hua; Mattaini, Katherine R; Metallo, Christian M; Fiske, Brian P; Courtney, Kevin D; Malstrom, Scott; Khan, Tahsin M; Kung, Charles; Skoumbourdis, Amanda P; Veith, Henrike; Southall, Noel; Walsh, Martin J; Brimacombe, Kyle R; Leister, William; Lunt, Sophia Y; Johnson, Zachary R; Yen, Katharine E; Kunii, Kaiko; Davidson, Shawn M; Christofk, Heather R; Austin, Christopher P; Inglese, James; Harris, Marian H; Asara, John M; Stephanopoulos, Gregory; Salituro, Francesco G; Jin, Shengfang; Dang, Lenny; Auld, Douglas S; Park, Hee-Won; Cantley, Lewis C; Thomas, Craig J; Vander Heiden, Matthew G.
Nat Chem Biol
; 8(10): 839-47, 2012 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-22922757
Pyruvate kinase M2 at a glance.
<i>O-</i>GlcNAcylation destabilizes the active tetrameric PKM2 to promote the Warburg effect.
A Novel Role for Pyruvate Kinase M2 as a Corepressor for P53 during the DNA Damage Response in Human Tumor Cells.
Purification and characterization of skeletal muscle pyruvate kinase from the hibernating ground squirrel, Urocitellus richardsonii: potential regulation by posttranslational modification during torpor.
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[Novel mechanism for invasion and metastasis involving metabolic enzymes in intractable cancer cells].
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Whole-protein alanine-scanning mutagenesis of allostery: A large percentage of a protein can contribute to mechanism.
Pyruvate kinase M2: multiple faces for conferring benefits on cancer cells.