Mutational processes molding the genomes of 21 breast cancers.
Nik-Zainal, Serena; Alexandrov, Ludmil B; Wedge, David C; Van Loo, Peter; Greenman, Christopher D; Raine, Keiran; Jones, David; Hinton, Jonathan; Marshall, John; Stebbings, Lucy A; Menzies, Andrew; Martin, Sancha; Leung, Kenric; Chen, Lina; Leroy, Catherine; Ramakrishna, Manasa; Rance, Richard; Lau, King Wai; Mudie, Laura J; Varela, Ignacio; McBride, David J; Bignell, Graham R; Cooke, Susanna L; Shlien, Adam; Gamble, John; Whitmore, Ian; Maddison, Mark; Tarpey, Patrick S; Davies, Helen R; Papaemmanuil, Elli; Stephens, Philip J; McLaren, Stuart; Butler, Adam P; Teague, Jon W; Jönsson, Göran; Garber, Judy E; Silver, Daniel; Miron, Penelope; Fatima, Aquila; Boyault, Sandrine; Langerød, Anita; Tutt, Andrew; Martens, John W M; Aparicio, Samuel A J R; Borg, Åke; Salomon, Anne Vincent; Thomas, Gilles; Børresen-Dale, Anne-Lise; Richardson, Andrea L; Neuberger, Michael S.
; 149(5): 979-93, 2012 May 25.
Artigo em Inglês | MEDLINE | ID: mdl-22608084
Transcriptome-wide off-target RNA editing induced by CRISPR-guided DNA base editors.
Expansions, diversification, and interindividual copy number variations of AID/APOBEC family cytidine deaminase genes in lampreys.
Epitranscriptomic profiling across cell types reveals associations between APOBEC1-mediated RNA editing, gene expression outcomes, and cellular function.
DART-seq: an antibody-free method for global m<sup>6</sup>A detection.
Epigenetic reprogramming: is deamination key to active DNA demethylation?
BE-FLARE: a fluorescent reporter of base editing activity reveals editing characteristics of APOBEC3A and APOBEC3B.
Pancancer analysis identifies prognostic high-APOBEC1 expression level implicated in cancer in-frame insertions and deletions.
Loss of APOBEC1 RNA-editing function in microglia exacerbates age-related CNS pathophysiology.
AID/APOBEC deaminases disfavor modified cytosines implicated in DNA demethylation.
Mitochondrially-targeted APOBEC1 is a potent mtDNA mutator affecting mitochondrial function and organismal fitness in Drosophila.