Strategies to mitigate the bioactivation of 2-anilino-7-aryl-pyrrolo[2,1-f][1,2,4]triazines: identification of orally bioavailable, efficacious ALK inhibitors.

Mesaros, Eugen F; Thieu, Tho V; Wells, Gregory J; Zificsak, Craig A; Wagner, Jason C; Breslin, Henry J; Tripathy, Rabindranath; Diebold, James L; McHugh, Robert J; Wohler, Ashley T; Quail, Matthew R; Wan, Weihua; Lu, Lihui; Huang, Zeqi; Albom, Mark S; Angeles, Thelma S; Wells-Knecht, Kevin J; Aimone, Lisa D; Cheng, Mangeng; Ator, Mark A; Ott, Gregory R; Dorsey, Bruce D.
J Med Chem; 55(1): 115-25, 2012 Jan 12.
Artigo em Inglês | MEDLINE | ID: mdl-22141319